The inability to mount spinal EM2 antinociception throughout defined stages with the estrus (and presumably menstrual) cycle and impaired transition from spinal EM2 analgesically nonresponsive to responsive physiological states could be causally connected with the perfectly-documented increased severity and frequency of chronic intractable discomfort syndromes in women vs Gentlemen. https://annb580bdf5.wikinstructions.com/user