DNA ligases seal five′-PO4 and three′-OH polynucleotide finishes by means of a few nucleotidyl transfer methods involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are important guardians of genomic integrity, and ligase dysfunction underlies human genetic disorder syndromes. Crystal constructions of DNA ligases bound to nucleotide and nucleic acid substrates https://fun8872592.affiliatblogger.com/80295943/top-guidelines-of-ligaz-slots