Environmental or self-antigens and homotypic interactions set off BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other signals through the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic scientific tests have discovered recurrent mutations in genes regulating tumor mobile-microenvironment in... https://ashleyw988jyn5.blog-ezine.com/profile