There is a release of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors during the dorsal horn to reduce afferent ache transmission and produce analgesia. For that reason, medications like clonidine that target alpha-two receptors can affect the transmission of agony. On the list of theories https://www.proleviate.com/post/the-new-pain-killer-conolidine