You will find a release of norepinephrine from the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors from the dorsal horn to reduce afferent soreness transmission and create analgesia. Thus, drugs like clonidine that concentrate on alpha-two receptors can influence the transmission of suffering. Applies to clonidine: oral pill, https://kbookmarking.com/story19711597/the-definitive-guide-to-onolidine